OCT: Macular thickness in insulin-dependent patients without evident retinopathy: a preliminary study
di
R. Malagola, R. Giannotti, L. Arrico
Objectives. Aim of this study was to evaluate whether OCT would
be able to show subclinical retinal modifications in diabetic patients
not showing clinical alterations during routine comprehensive eye
examinations. Furthermore, we analyzed whether there is a seat of topographical
macular predilection for the alterations and the connection
between their onset and the duration of the disease.
Materials and Methods. 39 Caucasian subjects, aged between 13
and 33 years, were enrolled. 20 of them were healthy subjects, and 19
were patients affected by insulin-dependent type I diabetes mellitus.
OCT scans were performed on all subjects, and macular thickness maps
were obtained. Macular thickness was compared between diabetic and
healthy subjects. Diabetic patients were divided in two subgroups, on
the basis of disease duration (≤/> 16 years), and compared with two
age-matched subgroups of healthy subjects.
Results. According to medical literature, macular thickness is
significantly greater in men than in women. No further statistically
significant differences could be detected in macular thickness if the
disease has been lasting for 16 years or less. On the other hand, a statistically
significant increase was detected in temporal macular thickness
in patients affected by diabetes for more than 16 years.
Conclusions. In patients affected by insulin-dependent diabetes
for more than 16 years OCT detects early subclinical alterations in
peripheral temporal macular region. Clin Ter 2012; 163(6):e393-396
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