No association between catalase (CAT) gene polymorphisms and susceptibility to vitiligo in a Turkish population
doi: 10.7417/CT.2013.1564
di
H. Akbas, S.B. Dertlioglu, F. Dilmec, M. Balkan
Background and Aims. Vitiligo is an acquired hypomelanotic skin
disorder resulting from the loss of functional melanocytes from the
cutaneous epidermis. Low catalase (CAT) activity and Accumulation
of hydrogen peroxide (H2O2) have been demonstrated in the epidermis
of vitiligo patients. Some polymorphisms on catalase gene may have
effect on the quantity and activity of catalase enzyme. The aim of this
study was to investigate whether catalase (CAT) gene polymorphisms
are associated with susceptibility to vitiligo in Turkish population. Materials and Methods. One hundred and three patients with vitiligo
and one hundred and seven gender, age and ethnic matched controls
were enrolled in the study. Genotyping was done by polymerase chain
reaction-restriction fragment length polymorphism (PCR-RFLP). Results. The CAT gene -89A>T (rs7943316) and 389C>T
(rs769217) genotypes and allele frequencies of vitiligo patients did
not differ significantly from those of healthy controls. Conclusions. We found no association between CAT gene -89A>T
and 389C>T polymorphism and vitiligo susceptibility in Turkish
vitiligo patients. Further studies with greater sample size should be
performed to verify these results. Clin Ter 2013; 164(3):e173-177.
doi: 10.7417/CT.2013.1564
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